Researchers found that a large portion of latently infected T cells are "activation inert." Essentially, the virus doesn't just hide; it sits within a cellular environment that has been significantly rewired to ignore typical "wake-up" signals like TCR/CD3 stimulation. Key Takeaways:
Extensive changes in the cell's proteins (the proteome) and gene expressions (the transcriptome) effectively "quench" the signals that should trigger the virus to reactivate. 8137 epub
This research shifts the focus from just the virus to the , offering a roadmap for future HIV cure strategies. Researchers found that a large portion of latently
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