: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March
: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies : Upon re-exposure, allergens cross-link IgE on the
Atopy typically follows a predictable chronological progression: : Upon re-exposure
While there is currently no cure, management focuses on controlling inflammation and restoring barrier function. Atopy - StatPearls - NCBI Bookshelf - NIH : Upon re-exposure, allergens cross-link IgE on the