Primary splenic lymphomas account for less than 1% of all non-Hodgkin lymphomas (NHL). Unlike nodal lymphomas, these diseases typically present with massive splenomegaly without significant lymphadenopathy. Accurate diagnosis is critical, as treatment varies significantly from other B-cell malignancies. 2. Classification of Splenic B-Cell Lymphomas
Peripheral blood smears often show "villous" lymphocytes (small cells with polar cytoplasmic projections). Immunophenotyping: Flow cytometry typically reveals Download Lymphomes splГ©niques pdf
Now reserved for refractory cases or emergency management of splenic rupture. Primary splenic lymphomas account for less than 1%