: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control.
In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure.
: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning.
This paper examines the two-part Season 4 finale of House, M.D. , comprising the episodes "" (S4E15) and " Wilson’s Heart " (S4E16). It explores how the narrative utilizes a traumatic bus crash to deconstruct Gregory House’s psyche, the fragility of memory, and the "cosmic unfairness" of life. The Quest for Memory
: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes
: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure