George struggles with his guilt after admitting he loves Izzie, while Callie, as Chief Resident, is overwhelmed by her duties and her suspicions that George is cheating.
The residents and interns treat victims of a massive apartment fire caused by a meth lab explosion. Alex Karev deals with a particularly difficult case involving a baby who suffered a stroke due to the meth lab environment.
The episode explores various forms of "addiction"—from chemical dependency to toxic emotional attachments—as the staff at Seattle Grace Hospital treats victims of a massive apartment explosion. Main Plotlines
![[S4E2] Love/Addiction](https://itnull.info/data/assets/notice_images/logo-og.png){kind=logo}