Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power
Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power tm,cc,jp
It tethers vesicles to the plasma membrane, facilitating sound encoding. Upon binding, a "closed" conformation is adopted, where
Structure and function of otoferlin, a synaptic protein of ... - PMC Ca 2+raised to the 2 plus power It
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,